Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Key projected targets for development this year:
3．50 First Dates
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Iron Man was Downey’s only movie of 2013, while Johnson had one huge film, Fast & Furious 6; one big film, G.I. Joe: Retaliation; and two smaller films. Together they added up to $1.3 billion at the global box office.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Wardrobe malfunctions was another common theme. Some hapless interviewees “showed up in sweatpants,” one “was wearing mismatched shoes,” and another “didn’t realize his zipper was down.”
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
"You're part of the past, but now you're the future," Lana Del Rey sings on Lust for Life's opening track, "Love".
vi. & vt
Let’s now travel to Greece. There, Andreas Georgiou, the head of its statistical agency between 2010 and 2015, faces prosecutions for his part in uncovering fake Greek public finance data for 2009 and setting the record straight. This week 40 groups, led by the American Statistical Association, and 651 individuals signed a statement in support of Mr Georgiou.
4. Booing isn't just for pantomimes
Trends and targets in antiviral phototherapy
Banks, asset managers and insurance companies have flocked from mainland China to acquire prime Hong Kong office buildings, prompting the territory’s government to announce it will release more land for commercial redevelopment in the oversubscribed heart of the city.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
In the 1990s, Roth applied it to the market for allocating US student doctors to hospitals. He developed a new algorithm that was adopted by the National Resident Matching Program, which helps match resident doctors with the right hospitals.
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
9.Yeah, I was a badass on my high school football team! – Because I want to be seen by others in an even stronger light than I see myself。
ACE2 as a potential therapeutic target for pandemic COVID-19
开发商：Remedy Entertainment、Microsoft Studios
节目20 小品《今天的幸福2》，沈腾 马丽 杜晓宇 王琦
Diagnostic technologies for COVID-19: a review
A disturbing and often bleak analysis of the automated future of work has been named 2015’s business book of the year.
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
德系三巨头：由于奔驰的几款低价产品不可避免地会损害它“要么最好，要么什么都不是”(the best or nothing)的商誉，该公司也开始陷入低迷。而即将推出的新7系轿车则会进一步巩固宝马在美国富人圈中的地位。另外，起价30,795美元的奥迪A3，很可能会使奥迪的销量较2014年增长15%，新款Q7也将进一步提高奥迪的利润。
But with a Republican-controlled State Senate, opponents of rent stabilization doubt that 2015 will be a watershed year for the tenants’ movement. Sherwin Belkin, a lawyer who represents landlords, said: “Landlords view this as an opportunity to make some much-needed changes to rent regulation.”
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
节目9 相声《这事儿不赖我》，曹云金 刘云天
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
这篇文章发表后，美国参议院很快投票通过了《反就业歧视法》（Employment Non-Discrimination Act）。这样，在工作中歧视LGBT群体也有可能成为违法行为。这项法案即将提交众议院审议。
There are 27 companies that are dropped from the list this year, including AT&T, IBM, Siemens and Xerox.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
I can't stop thinking that these children are my age, that it makes a tremendous difference where you are born, that I could be one of those children living in the Favellas of Rio; I could be a child starving in Somalia; a victim of war in the Middle East or a beggar in India. 我永远不能忘记这些和我同龄的孩子，当你出生的时候，他和我们真的很不相同，我也许生活在贫民窟，也可能是终日饿着肚子的小孩，也可能是中东战争的牺牲品，或者印度的小乞丐。
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
The magazine put his net worth at $3.5 billion, down $1 billion from the rankings it issued a year ago.
Antiviral drug discovery: broad-spectrum drugs from nature
7. “The Kindergarten Teacher” In his tough, weird knockout, the Israeli director Nadav Lapid spins the story of a teacher’s obsession with a child poet to create a savage portrait of fanaticism and its costs.
Influenza neuraminidase: A druggable target for natural products
2. “Inside Out” (Pete Docter)
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
The top obsession of 2010 was the much-anticipated iPhone, followed by actress Lindsay Lohan, the iPad, and the television shows "Glee" and "Jersey Shore".
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
His strategic shift away from corporate strategy was in spite of the fact that his own school had deterred him from making a career in education, even though he had worked as a private tutor.
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
France, one of the most visited countries in the world, ranks No. 9 overall. It is No. 2 in Cultural Influence and No. 6 in Power.
3. Not starting your own business
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
The CPI rose by 2 percent.
Mr. Russell's 1970s Abscam fictionalization 'American Hustle' had the better night overall, winning acting awards for Amy Adams and Jennifer Lawrence. Best picture was the only award for '12 Years a Slave,' which came in with seven nominations, tied for the most with 'American Hustle.'
On the sales front, General Motors and Ford F -0.13% lost market share to Chrysler, which leveraged its Jeep brand to previously unimagined heights – and then, metaphorically left its heritage behind when it established legal domicile in the Netherlands and changed its name to FCA US LLC.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
There are legitimate reasons to doubt that Nerlens Noel can blossom into a dependable starting center, including his injury history, off-court red flags, and extremely limited offensive game.
Inhibition of SARS coronavirus helicase by bismuth complexes
最佳迷你剧/电影：《美国罪案故事：公诉辛普森》(“The People v. O. J. Simpson: American Crime Story”, FX)
The country has rolled out measures to promote new-energy vehicles, including tax exemptions, subsidies for car purchases and a requirement for government departments to buy more new-energy cars.
Originally intended for the opening credits of Tomorrow Never Dies, and then for some reason relegated to the closing credits, K.D. Lang's "Surrender" is silken and cool. The horn sections are sassy and powerful. It's one of the best James Bond theme songs, and it's not even officially a James Bond theme song. And it's a heck of a lot better than the official theme the movie finally got.
"He was not on the intelligence services' radar," added the prime minister.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
OUTDOOR SPACE: The property is just shy of an acre and a half.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Kate Hudson spoke to British Elle magazine exclusively for this interview。 凯特·哈德森接受了英国ELLE杂志对她的独家专访。Does actress Kate Hudson know wha
I know a lot more about you when you walk in the door than you realize. I'll search for you on the web and often use my own personal network to do a pre-interview reference check.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
出手阔绰的美国公司正迫使英国同行提高从新入行者到顶级风云人物的薪资——尽管这并未阻止富尔德(Freshfields)的私募股权明星戴维希金斯(David Higgins)在圣诞节前夕跳槽到凯易律师事务所(Kirkland & Ellis)。精品专业律所通过提供更快、更专注的服务来吸引客户。
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
If you've got children, I understand that this isn't always possible. Children should always come first. But if you don't show up for your classes, you're not getting that education we discussed in No. 1.
The Queen would have been down the stairs like a shot as soon as the aircraft came to a final halt.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
“I think the best way to engage young people in the process is to win,” he says.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
5. It's a dog's life for the British
Last week, Lu was appointed director of the office for Beijing's Leading Group of Promoting Beijing-Tianjin-Hebei Integration Development, a move to accelerate Beijing's moves to coordinate with Tianjin and Hebei province.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
"The online Internet anti-corruption bid mostly relies on text, photos and videos and it is easy to be superficial if corrupt officials are only exposed this way."
"People can be unhappy for many reasons -- from poverty to unemployment to family breakdown to physical illness," the report said. "But in any particular society, chronic mental illness is a highly influential cause of misery. If we want a happier world, we need a completely new deal on mental health."
This includes ‘qwerty,’ in fourth place, ‘admin,’ in 11th, and ‘login’, in 14th.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
From 'heelgate' to the Palm Dog to the 'Dad bod' – it's been a dizzying 12 days. Here are nine lessons from the film festival as it draws to a close.
Best Companies rank: 32
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Morocco is a gateway to Africa. Major tourism cities in the North African kingdom include the capital of Rabat, Casablanca – the country's largest city - Marrakesh and Agadir.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
A modular microarray imaging system for highly specific COVID-19 antibody testing
The artefact which has a flat base was found inside an ancient tomb in the Xuyi County in western Jiangsu in 2009. It has been kept at the Nanjing Museum the capital of Jiangsu Province.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Scarlett Johansson of Captain America: Civil War was third at $25 million, down nearly 30 percent from 2015.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Company: (Wonderbag) Natural Balance
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
10.Michigan's Upper Peninsula, the US
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Who was buried here?
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Trade flows brought China’s balance of trade to $40.82bn, roughly $7.2bn below expectations and down about $3.6bn from November’s revised level of $44.23bn (previously $44.61bn). That balance came to Rmb275.4bn in local-currency terms.
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Recipient: Canadian Prime Minister Justin Trudeau
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
The programme focuses on the early careers of the children that are enrolled in the Abby Lee Dance Company in Pittsburgh, Pennsylvania.
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
The ranking of 95 schools, up from 90 last year, includes nine institutions, from seven countries, that were ranked for the first time. Frankfurt School of Finance and Management in 41st place is the year’s highest new entrant. The German school has one of the most gender-balanced programmes, with women accounting for 49 per cent of students.
Until now, testing reliably for lead was expensive and meant sending away samples for analysis.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
INDOORS: This house was completed around 1848 and last updated in 2008. The front door has a transom and sidelights of red glass etched with a leaf motif. The first floor has a large living room with crown molding and two fireplaces, one of which warms the formal dining area. Off the living room is a family room with raised wall paneling, a wet bar and another dining area. French doors open to a slate patio. Several rooms have views of Little Narragansett Bay.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Stallone's iconic underdog has spent decades inspiring athletes and nonathletes alike to fight for their goals. As a poor local boxer, Rocky gets his break when he enters a fight with World Heavyweight Champion Apollo Creed. Due to his rigorous training and Creed's relative apathy, Rocky becomes the first challenger to ever push Creed through all 15 rounds.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Of course, the recovery of the job market has been, and probably will remain, incremental. Job growth needs to be much stronger to actually make a big dent in unemployment, which remains high at 7.9%, though down from 10% three years ago.[qh]
Anti-HIV drug repurposing against SARS-CoV-2
Length-scale dependence of protein hydration-shell density
At the last minute he opted instead for Teach First, the educational charity that has become the UK’s biggest recruiter of new graduates. Rather than parachuting into companies that needed restructuring, Mr Ravenscroft started teaching business and economics at Cardinal Pole School, which serves 11-19 year old boys and girls in Hackney, east London.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Technically it is a project of the 10-member Association of Southeast Asian Nations to bring all of its trade deals in the region under one umbrella. It also lacks the ambition on many fronts of the TPP.
Local-level work experience will advantageous for applicants, with personnel with more than two years of experience at this level given some advantage.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
全食CEO约翰麦基的《自觉资本主义》（Conscious Capitalism）一书让公司高管们不得不思考这样一个观点，那就是处于最佳运转状态的企业能为所有利益相关方创造价值，而不仅仅是投资者。麦基认为，主要利益相关方包括顾客、员工、供应商、社会以及环境。他以好市多、西南航空（Southwest Airlines ，《财富》500强）和谷歌（Google，《财富》500强）为例，说明思维超越利润能够打造更强大而、更高效的公司。
Carry out deleveraging in an active and prudent way.
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“Even if you have made your peace with a Fed rate rise there are other reasons to be nervous,” said David Hauner, head of emerging markets at Bank of America Merrill Lynch, who points to falling oil prices and the slowdown in China to illustrate why market volatility measured by the CBOE’s Vix index, a barometer of investor sentiment, has been elevated since August.