Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
The dollar value of China’s exports and imports grew in November after two months of contraction and in the face of a rally by the greenback that followed last month’s US presidential election.
The contiguous United States set a temperature record in 2012, a year of scorching heat waves and drought. But, mostly because of the unusual chill in the East, 2014 was only the 34th warmest year on record for the lower 48 states.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
According to the financial data provider Wind Information Co Ltd, listed companies in China's A-share market earned 2.47 trillion yuan in profits last year. Of those listed companies, 2000 plan to pay out 700 billion yuan to their shareholders.
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
52% of the world lived in extreme poverty in 1981. This number dropped down by 21% in 2010, as 721 million fewer people no longer live in absolute poverty.
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
n. 游艇，快艇 vi. 驾快艇
Mr Erdogan’s escalation comes in the midst of a vitriolic tit-for-tat between Ankara and The Hague, which began at the weekend after Dutch officials barred Turkish ministers from campaigning in Turkish communities inside the Netherlands.
Loyal employees of this auto services company are rewarded on their 10th anniversary -- and every five years after --with a weekend getaway at a resort in Boca Raton, Fla. (The company is headquartered just 15 minutes away.)
Trends and targets in antiviral phototherapy
After Zhou contaminated the water, one of Zhou's classmates surnamed Tang noticed that the water coming out of the dispenser was milky and had a pungent scent.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
The Beijing Tourism Development Commission noted that the country's battle with pollution is another obstacle cities face in attracting inbound tourists.
Novel biosensing methodologies for ultrasensitive detection of viruses
World's Most International Universities Ranking 2016 by The Times Higher Education included 200 universities from 28 countries. It employed indicators such as the proportion of international staff, the number of international students and research papers published with at least one co-author from another country of each institution.
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Meanwhile, in an unfortunate red carpet faux pas, Pink and Shakira both showed up in the same Balmain dress.
ACE2 as a potential therapeutic target for pandemic COVID-19
China denies any wrongdoing and says it is working to tackle problems of industrial overcapacity that have become more acute as its economy has slowed.
Diagnostic technologies for COVID-19: a review
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
“BlackBerry has not engaged in discussions with Samsung with respect to any possible offer to purchase BlackBerry,” the company said in a statement issued Wednesday afternoon. “BlackBerry’s policy is not to comment on rumors or speculation, and accordingly it does not intend to comment further.”
But what drives the underlying optimism or pessimism? Koudijs, working with Hans-Joachim Voth at the UniversitatPompeuFabra in Barcelona, found surprising answers.
1. China’s Economy.China is the second largest consumer of oil in the world and surpassed the United States as the largest importer of liquid fuels in late 2013. More importantly for oil prices is how much China’s consumption will increase in the coming years. According to the EIA, China is expected burn through 3 million more barrels per day in 2020 compared to 2012, accounting for about one-quarter of global demand growth over that timeframe. Although there is much uncertainty, China just wrapped up a disappointing fourth quarter, capping off its slowest annual growth in over a quarter century. It is not at all obvious that China will be able to halt its sliding growth rate, but the trajectory of China’s economy will significantly impact oil prices in 2015.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
They are calculated using a methodology that focuses on a school's research performance and reputation, not its specific undergraduate or graduate programs. This is a separate methodology than those used for other US News rankings such as Best Colleges and Best Graduate Schools.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
《一个开车从来不回头看的沙特女子》(A Saudi Woman Who Got Behind the Wheel and Never Looked Back)
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
1999：H9N2传染人类1999: H9N2 Infects Humans
9. "Vikings" (2.3 million)
Influenza neuraminidase: A druggable target for natural products
Exports declined 6.9 per cent in October from a year earlier, deteriorating from the 3.7 per cent fall the previous month as weak global demand and higher Chinese costs led to slumping shipments of the cheap Chinese goods that have flowed to the world in the last decade.
“The Fed was much more aggressive than expected,” Mr Koepke says. “Taking markets by surprise was clearly not the way to go.” (This was before the Fed began making regular public statements after its monetary policy meetings.)
‘Jordan,’ ‘harley,’ ‘robert,’ ‘matthew,’ ‘daniel,’ ‘andrew,’ ‘andrea,’ and ‘joshua’ all made it on the list – along with ‘football,’ and ‘lakers.’
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
“Today you have to shop by image,” Mr. Nathan said. “But if you are brave and don’t follow fashion, there are opportunities.”
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
LONDON — In the 1970s, the British comedian Tommy Cooper used to tell a joke about asking an auction house to value a violin and a painting that he had discovered in an attic. The good news, he was told, is that they were made by Stradivarius and Rembrandt. The bad news was that the painting was by Stradivarius and the violin was by Rembrandt.
Harvard Business School, London Business School (LBS) and MIT Sloan School of Management, three of the MBA ranking’s longstanding heavyweights, all lost ground to their competitors. Harvard drops two places to fourth, the first time in nine years that the Boston school has been outside the top three. London Business School falls three places to sixth, its lowest position in 14 years. MIT Sloan School of Management falls to 13th place, the first time in 10 years that it has been outside the top 10.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
The film screens in China reached 41,179 as of the end of 2016 with another 1,612 cinemas and 9,552 film screens built during the year, according to a report by People's Daily.
Inhibition of SARS coronavirus helicase by bismuth complexes
Over the next few years, large residential buildings will have to comply with Local Law 87, which requires them to audit energy usage and keep systems running at peak efficiency. Residential buildings are the city’s largest source of greenhouse gas emissions, accounting for 37 percent of the total. “The one hot-button topic is energy. How do buildings become more energy efficient?” said Dan Wurtzel, the president of FirstService Residential New York, which manages more than 500 properties. “If a third of your operating budget is related to energy and you can now reduce that cost, you can take pressure off the need for a maintenance increase.”
1. What big brother is eating isn’t noodles, but loneliness.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
库克决定通过增加派息和回购股票扩大其现金返还计划，帮助缓和了与维权投资者的关系。目前它总共向股东返还现金940亿美元。最终，库克以足够的坚忍抵挡住挑战，迎来了iPhone又一波增长捷报，以及从乔纳森?艾夫爵士(Sir Jonathan Ive)的设计室诞生的新产品。
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
20. 对电影爱好者的最佳建议。8月学者韦勒·温斯顿·迪克森(Wheeler Winston Dixon)发出了警告：“如果你上亚马逊，看到什么精彩的黑白电影卖三美元，或者其他什么外国电影和鲜为人知的电影，赶快买下来，因为它就要绝版了，他们不会再出版它们了。”成千上万这种VHS格式的电影不会被做成DVD格式或蓝光格式，迪克森警告说。而下载的美丽新世界（又名电子销售）明年将是好年头。
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
By turns breathtaking, hilarious and disturbing, Jonathan Glazer’s extraordinary, erotic film achieves a rare blend of fantasy and realism
The cost of living the Australian dream has surged with Sydney and Melbourne among the five most expensive cities in the world, outstripping most European and US locations, according to an annual survey released on Monday.
This year's new college grads entering the workforce are being offered an average monthly salary of 4,014 yuan ($582), and about one-third of them chose to work in first-tier cities, according to survey results released by zhaopin.com, a Chinese online recruitment service provider.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
《法律与秩序：特殊受害者》(Law & Order: SVU)：NBC频道的这部电视剧上一季中的危机仿佛是从肥皂剧中搬来，发生了各种大事，奥利维亚（Olivia，玛莉丝卡·哈吉塔[(Mariska Hargitay]饰）经历了许多危险——喜欢跟踪的变态强奸犯，折磨人的婚外恋，新生婴儿，现在这一切终于平息下来。在今年的第16季中，侦探们回到了重要的性犯罪上，其中一集的灵感来自雷·赖斯(Ray Rice)，讲述的是从监控录像中看到一个著名体育广播员殴打自己的妻子。
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
9．The Bling Ring
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
The report didn't comment on potential factors influencing the numbers, but many – including members of the opposing political party – are laying the blame squarely at the feet of government cost-cutting.
It is the first time that EMBA-Global, the joint programme delivered by London Business School and Columbia Business School, has dropped out of the top five.
When researchers at the University of Illinois set out to create a device that identifies chemicals by their scent, they didn't settle for the sensitivity of the human nose. Instead, they created an artificial nose that uses the smell of bacteria to identify and diagnose specific diseases.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
1. "Game of Thrones" (5.9 million)
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
The Jungle Book will be released worldwide on April 15, 2016.
Contrary to the consensus view -- which assumes that smartphones in China will only get cheaper -- she cites research showing that the average selling price stablized last yearand has actually started to increase as Chinese users trade up to higher-quality smartphones.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
This groundbreaking fight is loosely based on a bout between Chuck Wepner and Muhammad Ali, in which the "everyman" Wepner managed to become one of the four men to knock Ali down in his career. Just like in the film, Wepner pushed Ali through 15 rounds despite looking (and feeling) like he'd been hit by a truck. While both he and Rocky ended up losing their fights on a technicality, Wepner wins in our book for inspiring such an awesome character.
Emily Ratajkowski managed to steal the show, opting for a seriously saucy twist on the classic ballgown. Opting for a semi-sheer lacey black number, the We Are Your Friends actress ensured her world-famous figure was on display.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
1. Apple. Brand love: 57% / Rank: 32
A modular microarray imaging system for highly specific COVID-19 antibody testing
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
So I don't know what will happen in 2014--and neither does anyone else. What I imagine, though, looks like this:
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Aoki-san is a pleasure to work withon storyboard. With Aoki-san on the team it feels like a sure thing. The visionof these animations will be perfect.
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
9) I would rather keep people at a distance 0 1 2 3 4
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Beijing is pushing hard to conclude the Regional Comprehensive Economic Partnership by the end of the year. The deal has long been called China’s answer to the Trans-Pacific Partnership and its bid for regional trade hegemony.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
The latest government figures were a big jump from data in mid-December, when1,200 people were said to have left or are seeking to leave to battle alongside jihadists.
A facile assay for rapid detection of COVID-19 antibodies
I know many of you met your former spouse at the company. But the thing is, for every one of you, there are five people it doesn't work out as well for. And your office romance can and will be held against you.
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
The Atlanta-based group expects sales, adjusted for acquisitions, divestitures and currency fluctuations, to rise 3 per cent, compared with its earlier forecast of between 4 per cent and 5 per cent.
《出生于缅甸皇室的她成为军阀和大毒枭》(The Female Warlord Who Had C.I.A. Connections and Opium Routes)
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
陆金所是最大的一家。它是中国平安保险(Ping An Insurance)的子公司，平安也是陆金所最大的股东。
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
If there are nine or 10 best picture nominees, it could grab a spot. Jordan Peele's screenplay looks certain to be recognized.
For: The Los Angeles Critics Association gave it their top prize.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
总部位于芝加哥的竞争对手科尔尼(AT Kearney)也在为领导层变动做准备，计划于2018年第一季度投票决定接替约翰奥利格(Johan Aurik)的人选。管理合伙人最多担任两个任期，而奥利格已经期满。预计他的继任者将专注于让科尔尼做大，摆脱中等规模参与者之列。
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
1. Bubble With No Name Yet triggers the biggest crash in 30 years
Length-scale dependence of protein hydration-shell density
'It's going to get volatile to the upside,' he said.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
6. 《出租车》(Taxi)，导演贾法·帕纳西(Jafar Panahi)。
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
The decaying feet, some dating back to 1967, were being 'cleaned up', plumped up and whitened at the 'foul-smelling' plant using bleach and other chemicals, before being prepared for sale.
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